The most frequent significantly mutated genes (SMGs) across the 430 cervical carcinomas were previously reported5,6,8–11 and included PIK3CA (27%), KMT2C (also known as MLL3) (19%), KMT2D (also known as MLL2) (13%), EP300 (12%), FBXW7 (12%), FAT1 (8%), and PTEN (8%) (Supplementary Table 3). Here, KMT2C is linked to cervical carcinoma.