ERBB2 and cancer: In previous studies, aptamers (such as AS1411, anti-HER2 aptamer (HApt), and SL2B), antibodies and proteins (affibody, FA) were conjugated with TDNs for cancer cell recognition and inhibition.437–439 Coupled with the loading of therapeutical agents like 5-fluoroutacil (5-FU), DOX, paclitaxel (PTX), the products were supposed to selectively enter cancer cells and exert potent antitumor effects.88,107,426