Its overexpression is associated with malignancy and the poor prognosis of breast cancer.440 According to previous work, HApt could be specifically chosen to bond with HER2 and supress its expression.441,442 With this in mind, HApt-TDNs was prepared to specifically combine with HER2 and then transfer it into lysosome for the following degradation. This evidence concerns the gene ERBB2 and breast cancer.