BUB1B and Miyoshi myopathy: Besides, cell cycle analysis demonstrated that enforced expression of BUB1B elicited prominent increment of G2/M phase proportion (p < 0.01) (Fig. 1h, i), while attenuated expression of BUB1B resulted in the remarkable decreased proportion of G2/M phase in MM cells (p < 0.01) (Fig.1j, k).