CEP170 and cervical squamous intraepithelial neoplasia: Previous studies have reported that CEP170 directly interacts with centrosome-associated kinesins KIF2A and KIF2C, and this construct acts as a key part in metaphase spindle size control.40 CEP170 is phosphorylated by polo-like kinase 1, and plays an important role in maintaining microtubule organization and cell morphology.21 Our data showed that BUB1B directly interacted with and phosphorylated CEP170 at the Ser1260 site, the mutation of which disrupted the interaction between BUB1B and CEP170, and then abolished the CIN characteristics induced by CEP170 OE.