IF staining result indicated that circBUB1B_544aa OE led to significant increments in chromosomal plate width and reductions in mitotic spindle length upon BTZ or ADR treatment in CAG and H929 cells compared to WT cells, implicating that circBUB1B_544aa was capable of inducing CIN to promote MM drug resistance as well as BUB1B (Fig. 6f–i). The gene discussed is BUB1B; the disease is cervical squamous intraepithelial neoplasia.