We found that knockdown of CEP170 in circBUB1B_544aa OE cells abrogated CIN in MM, as indicated by decreased chromosomal plate width and increased mitotic spindle length compared to non-treated circBUB1B_544aa-OE cells (Fig. 6k, Supplementary Fig. 2f). Here, CEP170 is linked to cervical squamous intraepithelial neoplasia.