The cell–cell interactions between MDSCs and macrophages can elicit a type 2 tumor-promoting immune response, which is mediated by elevated IL-10 production in MDSCs and downregulated IL-12 production in macrophages.124 Overall, MDSCs together with other immune suppressive cells build an inhibitory network, crippling the cytotoxic effects on tumor cells. Here, IL10 is linked to neoplasm.