SELL and neoplasm: In a lung cancer mouse model, MDSCs inhibited the differentiation and function of B cells by modulating IL-7 and downstream STAT5 signaling.118 In a breast cancer mouse model, MDSCs upregulated PD-L1 expression on B cells, and further transformed them into regulatory B cells (Bregs) which had higher inhibitory abilities on T cells.119 What’s more, splenic MDSCs from tumor-bearing mice were reported to downregulate the adhesion molecule L-selectin on splenic B cells, resulting in reduced B cells homing to lymph nodes.120