IL1B and neoplasm: In contrast, pulmonary-infiltrating PMN-MDSCs supported the metastatic tumor growth through reverting EMT/CSC phenotype and promoting tumor cell proliferation.143 In glioblastoma (GBM) mouse models, proliferating M-MDSCs were predominant in the tumors of males, while a high PMN-MDSC/IL-1β gene signature was correlated to a poor prognosis in females.