Furthermore, the combination of etomoxir with low-dose chemotherapy completely abrogated the immunosuppressive function of tumor-infiltrating MDSCs.141 Besides, a previous study reported that GM-CSF signaling induced the overexpression of fatty acid transport protein 2 (FATP2) in PMN-MDSCs through activation of STAT5, and FATP2 in turn modulated the immunosuppressive function of PMN-MDSCs through uptake of arachidonic acid and synthesis of PGE2. The gene discussed is SLC27A2; the disease is neoplasm.