Some neurotrophins were studied in different dermatological conditions.9, 10, 12, 13, 14 In several skin chronic inflammations, such as atopic dermatitis, psoriasis, and prurigo, NGF expression was increased in the lesions.25, 26, 27 In fact, the number of peripheral nerve fibers and the concentration of NGF in LSC lesions have been reported to be higher. This evidence concerns the gene BDNF and neoplasm.