APP and Alzheimer disease: In conclusion, our study sheds light on how low-grade peripheral inflammation affects AD pathogenesis in a new mouse model of AD, namely the AppNL-G-F model [53], which overcome intrinsic drawbacks of the APP overexpression mouse models by utilizing an App knock-in strategy were generated to overproduce pathogenic Aβ such as Aβ1-42 without overexpressing APP.