Through performed a case-control analysis comprising 506 patients with RA and 509 healthy controls in the Chinese Han population, our study is the first to elucidate the relationship between FCRL1 rs2050568, FCRL3 rs2317230, FCRL6 rs58240276 polymorphisms and RA in the Chinese Han population. Here, FCRL3 is linked to rheumatoid arthritis.