CD4 and mature T-cell and NK-cell non-Hodgkin lymphoma: In 2016, Pinz et al. generated third-generation CD8+ CD4-redirected CAR-Ts and reported that these cells exhibited exclusive antitumor activity towards a CD4-expressing cell line (KARPAS 299 cells) and patient-derived PTCL cell samples while retaining their memory stem cell-like phenotype [70].