In summary, we have shown that at doses previously shown to extend lifespan, dietary Rap (14 ppm) and Rap+Met (14 + 1000 ppm) caused hyperglycemia and was associated with aggravated OA in Dunkin Hartley guinea pigs despite inhibiting mTORC1 in articular cartilage. This evidence concerns the gene LRPAP1 and Hyperglycemia.