BDNF and herpes simplex infectious disease: KEGG pathway were as follows: PI3K/AKT signaling pathway, Wnt/β-catenin signaling pathway, HTLV-I infection, Notch signaling pathway, MAPK signaling pathway, Neurotrophin signaling pathway, Long-term potentiation, Dopaminergic synapse, Endocytosis, and Herpes simplex infection (Fig. 6 C).