IKBKB and cancer: Subsets of these frequent UMGs encode subunits of proteins and members of protein complexes with a strong association with cancer (e.g., PIK3R2/R3/CB/CD’s products in phosphatidylinositol kinases (PI3Ks) [34], and IKBKB/G’s products that are regulatory subunits in an inhibitor of the Nuclear Factor Kappa B kinase (NFKB) [35]).