PRL and hyperprolactinemia: Although this differs somewhat from the recommendations of the Endocrine Society Guidelines and guidelines published by the Spanish Society of Endocrinology and Nutrition and the Brazilian Society of Endocrinology and Metabolism [25–27], we insist that it is necessary to perform macroprolactinemia screening for those with an apparent idiopathic hyperprolactinemia, no obvious cause for the hyperprolactinemia, atypical clinical picture, conflicting prolactin results in distinct assays or delayed decline of serum prolactin levels with the usual doses of dopamine agonists.