The PFS and OS time period of the ERBB4-MT NSCLC patients (21/350) treated with ICIs was longer than that of the ERBB4-WT patients (329/350) (the median PFS: 9.2 vs 3.17 months, p = 0.0360; the median OS: 21 vs 11 months, p = 0.0378, Fig. 1B, C). The gene discussed is ERBB4; the disease is non-small cell lung carcinoma.