Given the critical role of RRBP1 in regulating ER stress‐induced apoptosis and hitherto confirmed interaction between USP35 and RRBP1, we further demonstrated that overexpression of USP35 protected NSCLC cells from ERS‐triggered apoptosis, while silencing USP35 exacerbated this phenotype, indicating anti‐apoptotic role of USP35 during ERS. This evidence concerns the gene RRBP1 and non-small cell lung carcinoma.