Notably, compared to a modest increase in CD8+/CD4+ T cell ratio induced by IL-2 treatment in the model of influenza infection (Fig 2J), the same treatment in acute LCMV infection led to an approximately 3-fold increase in the CD8+/CD4+ T cell ratio in both spleen and inguinal lymph nodes (Fig 3E). The gene discussed is CD4; the disease is influenza.