In addition, despite an enrichment of typically regulatory M2-like macrophages in the COVID-19 nasal wash samples, a comparison of transcripts from M2-like macrophages revealed a dramatic increase in proinflammatory genes related to IL-1β and chemotaxis in COVID-19 samples compared with influenza samples (Table 3 and Supplemental Data File 3). This evidence concerns the gene IL1B and COVID-19.