Relevant to this, we looked at ELAVL3 in three ALS-related mouse models—TDP-43ΔNLS, C9orf72, and SOD1 (G93A)—and our preliminary observations in three mice of each model and three respective wild-type littermates support the observation of ELAVL3 nuclear depletion and align with our observations in human samples, although additional studies are needed (Supplementary Fig. 6). This evidence concerns the gene ELAVL3 and amyotrophic lateral sclerosis.