C9orf72 and amyotrophic lateral sclerosis: Relevant to this, we looked at ELAVL3 in three ALS-related mouse models—TDP-43ΔNLS, C9orf72, and SOD1 (G93A)—and our preliminary observations in three mice of each model and three respective wild-type littermates support the observation of ELAVL3 nuclear depletion and align with our observations in human samples, although additional studies are needed (Supplementary Fig. 6).