SLC9A6 and Alzheimer disease: In addition, genome-wide association studies (GWAS) in conjunction with studies on cell culture and mouse models of AD show that various AD risk factors enhance endolysosomal dysfunction (Knopman et al., 2021; Small et al., 2017; Verheijen and Sleegers, 2018), which potentially could be corrected by NHE6 inhibition.