SCN5A and Arrhythmia: Scn5a+/− also showed accentuated QT dispersions, shortened ventricular action potential durations particularly involving the right ventricle recapitulating clinical observations (Ikeda, 2001) (Pitzalis et al., 2003), that may form the bases of both ST elevation and arrhythmia in BrS (Yan & Antzelevitch, 1999).