Wu et al.3first identified heterozygous frameshifting mutations in the RCBTB1 gene in three cases from two unrelated Taiwanese families with Coats disease (OMIM #200216) and familial exudative vitreoretinopathy (FEVR, OMIM #133708), respectively. Here, RCBTB1 is linked to Familial exudative vitreoretinopathy.