Analysis of further CHH families suggested that self‐limited DP and CHH may share some overlap of their pathophysiology, with homozygous mutations in genes such as GNRHR67, 68 and TAC3 and its receptor68 causing CHH, while heterozygous carriage of the same variants was associated with the milder phenotype of self‐limited DP.67, 68, 69. The gene discussed is TAC3; the disease is cartilage-hair hypoplasia.