Aged microenvironment induces E‐CAD delocalization from cell membrane to cytosol, increases the expression of MMP2, pro‐inflammatory cytokines (IL8, MIF, GM‐CSF, TNFα, IL1, and IL4), uPA system components (SERPINE1, ANG, OPN, and uPAR), and several cancer‐related proteins (ANGPTL4, KLK5, MMP3, GAL3, VIM, HERs, CapG, HO, CTSD, and AFP), all involved in cancer progression. Here, SPP1 is linked to cancer.