Of particular interest were Cd14, which is involved in EMT, tumor invasion and progression, and establishing proinflammatory tumor microenvironment,[48, 49, 50] Ccl21, which has been shown to induce melanoma cell metastasis in mice,[51] and Cd40, which is known to induce cell migration.[52] Higher stiffness of the aged matrix in combination with the high cytokine content could be the reason for the high proinflammatory and cancer‐associated cytokine and protein production by the epithelial cells. Here, CCL21 is linked to melanoma.