Our results also indicate that LOX knockdown leads to decreased expression of aging‐associated proteins that are involved in cancer progression and cell migration and invasion, including the intracellular (galectin 3, CapG, HO1, SNAI, mesothelin, and AFP), surface (E‐CAD, HER, HER2, HGFR, and thrombospondin 1), and extracellular (MMPs and cathepsins) proteins, cytokines (IL8, MIF, IL1α, IL4, CCL2) and growth factors (TGFβ, GDF15, FGF, and angiopoietin 2). This evidence concerns the gene THBS1 and cancer.