Similar to the cytokine profiling results, most of the cancer‐associated proteins, such as ANGPTL4, KLK5, GAL3, VIM, HERs, CAPG, HO, CTSD, and AFP were produced at higher levels on the aged matrix, but were reduced to young matrix levels after LOX siRNA treatment (Figure 5E, and Figure S7B and Table S5, Supporting Information). Here, CTSD is linked to cancer.