Although it was considered to have tumor suppressor functions in acute myeloid leukemia,71 the recent study of Zhang found that miR‐193b‐3p was upregulated in NSCLC, which verified the miR‐193‐193b‐3p could serve as a biomarker of NSCLC,72 our findings further revealed that the overexpression of miR‐193b‐3p might have relationships with the KEAP1/NFE2L2/CUL3 mutations. This evidence concerns the gene CUL3 and acute myeloid leukemia.