BCL2A1 and cancer: Glutathione S‐Reductase(GRS) gene, encoding glutathione (GSH) reductase, had a crucial role in the cancer progression and treatment response via the metabolic of glutamine in TME, and Baity et al. found that GSR copy number loss is common in LUAD, which might be a biomarker for personalized therapy in the future.63, 64