ANGPT2 and melanoma: HOXB7 stimulates angiogenic response by inducing the important pro-angiogenic factors such as bFGF, vascular endothelial growth factor (VEGF), melanoma growth-stimulatory activity/growth-related oncogene alpha (MGSA/GRO-α), interleukin-8 (IL-8), and angiopoietin-2 (Ang-2) (Carè et al. 2001).