Elevated HOXB7 has been demonstrated in the peripheral lymphocytes in ALL patients whose progression is attributable to the HOXB7-mediated activation of basic fibroblast growth factor (bFGF) and extracellular signal-regulated kinase (p-ERK1/2) and inactivation of p27 (Zhong et al. 2019). The gene discussed is FGF2; the disease is acute lymphoblastic leukemia.