In head and neck squamous cell carcinoma (HNSCC), HOXB5 functions as an oncogene, which binds directly to the promoter region of EGFR and regulates the AKT/Wnt/β-catenin synergistic signaling axis to enhance proliferation, cell migration, invasion, and EMT (Lee et al. 2020). The gene discussed is AKT1; the disease is head and neck squamous cell carcinoma.