The stable HOXD8 expression in CRC cell lines upregulated the expression of executioner caspase-6 and caspase-7 (CASP6/CASP7) and cleaved poly(ADP-ribose) polymerase (PARP) to induce apoptosis in CRC cells (Mansour and Senga 2017). Here, CASP7 is linked to colorectal carcinoma.