In BC and non-small cell lung cancer (NSCLC), knockdown of HOXB5 significantly suppressed the β-catenin protein and its downstream targets c-Myc and CCND1, thereby inhibiting cell proliferation, migration, invasion, and EMT of the cancer cells (Zhang et al. 2018a; Zhang et al. 2020). This evidence concerns the gene CCND1 and non-small cell lung carcinoma.