The overexpression of Wnt signaling–related genes and their downstream targets such as matrix metalloproteinase-2 (MMP2), c-Myc, CCND1, and vimentin (VIM) indicates the involvement of Wnt/β-catenin signaling in HOXB8-overexpressed CRC cells (Li et al. 2019e). This evidence concerns the gene MMP2 and colorectal carcinoma.