HMGB1 and neoplasm: Although treatment with GL alone (labeled EC18H + GL in pink) reduced basal tumor growth (compared with EC18H in blue), we showed that the addition of anti-HMGB1-mAb, and to a greater extent with GL, reversed the HMGB1-induced B-cell activation in tumor growth to a basal level (150% and 215% reduction in the effect of B cells mixed with EC18H, Fig. 8c).