Contrary to a report which demonstrated a proangiogenic phenotype in IgG4-switched memory B cells [16], we found that B-cell-specific gene expressions (i.e., BACH2 and PAX5), rather than plasma cell (PC)-associated genes (i.e., PRDM1), were induced in B cells when co-cultured with HMGB1-overexpressing tumor cells (Supplementary Fig. 8a). This evidence concerns the gene HMGB1 and neoplasm.