The results showed that the average sprout length in HUVECs treated with CM from co-culturing B cells with HMGB1-overexpressing tumor cells at 72 h was significantly longer (3.716 ± 5.062 μm/spheroid) than in those treated with control medium (1.692 ± 2.535 μm/spheroid). This evidence concerns the gene HMGB1 and neoplasm.