We have recently shown an increased infiltration of type 2 macrophages in tumor stroma of FOXO1-positive ESCC tissue [8], while others have reported high accumulation of CD20+ B cells in the tumor nest of ESCC [9] and that abundant intratumoral CD20+ B cells and CD8+ T cells are associated with better outcomes in patients with oropharyngeal squamous cell carcinoma (OPSCC) [10]. Here, FOXO1 is linked to neoplasm.