BCL2 and melanoma: Comparison of a transfected MelHO melanoma subline overexpressing Bcl-2 and a Jurkat T-cell leukemia subline overexpressing Smac with the respective vector-only controls showed no differences in the extent of DNA fragmentation upon treatment with KP772, suggesting that KP772-induced cell death is independent of the anti-apoptotic protein Bcl-2 and the pro-apoptotic factor Smac (Fig. 5).