However, as in patients with abnormal (< 1000 cell/mm3) posttreatment PLC, the most common tumor locations were the temporal and parietal lobes (58.1% in AAL vs 30.8% in non-AAL), both supplied by the middle cerebral artery, it is conceivable that the irradiation of brain areas supplied by the largest branch of the internal carotid [32] might have resulted in a more relevant PLC depletion, thus overcoming the effect of other factors. Here, HSPG2 is linked to neoplasm.