In summary, while the properties of aortas from F13a1–/– and Tgm2–/– single knockout mice appeared similar to C57Bl/6J wild-type mice, there were detectable differences in the basal state of Tgm2–/–/F13a1–/– double knockout aortas that could affect their response to aneurysm development. Here, TGM2 is linked to aneurysm.