Metformin normalized vascular function, partly in perivascular adipose tissue, inhibited increases in mRNA expression of osteopontin (SPP1) and MMP12 (genes involved in aortic aneurysms), and mRNA expression of Gpnmb- and Clec7a-encoding glycoproteins, which are expressed by various leukocytes. Here, SPP1 is linked to aortic aneurysm.