EZH2 and breast cancer: DZNep effectively decreases the expression of PRC2 proteins EZH2, SUZ12, and EED, as well as global H3K27me3 levels, leading to the reactivation of the PRC2-repressed genes and apoptosis in breast cancer cell line MCF-7 and colorectal cancer cell line HCT116, but not in normal cells (240).