However, frequent mutations in some subunits, such as MGA and BCOR/BCORL1, as well as generally high mutation rates in cancers such as diffuse large B-cell lymphoma (DLBCL) and cholangiocarcinoma of the bile duct (CHOL) point to specific roles for Polycomb subunits in tumor suppression. The gene discussed is MGA; the disease is diffuse large B-cell lymphoma.