PBRM1 and ovarian carcinoma: Other SWI/SNF altered cancers that are dependent on EZH2 include SS18-SSX translocated synovial sarcoma (168), ARID1A-mutated ovarian cancer (169), SMARCA4-mutated lung (170) and ovarian cancers (171), and PBRM1-mutated renal cancers (172).