Competes with SAM-e for the EZH2 SET domain, leading to reduction of H3K27 trimethylation levels without affecting the protein levels of EZH2, SUZ12, and EED. CPI-360 has antiproliferative effects in different lymphoma cell-based models as well as in a human B-cell non-Hodgkin lymphoma murine model. Here, EED is linked to B-cell non-Hodgkin lymphoma.