And pathways correlated with the tumor recurrence, such as regulation of telomerase pathway, SMAD2/3/4 heterotrimer-regulated transcription pathway and the activation of NIMA kinases pathway, were significantly activated, while the pathways involved in the DNA damage repair pathways, such as recognition and association of DNA glycosylases pathway and the cleavage of the damaged purine pathway, were inhibited. The gene discussed is SMAD2; the disease is neoplasm.