The presence of TGF-β1, as a cytokine that can suppress NK cells cytotoxicity, in tumor-derived exosomes may contribute to the suppression of NK cells activity in cancers [75], which can be verified by the rescue of exosome-mediated NKG2D reduction in NK cells upon TGF-β1 neutralization [74]. This evidence concerns the gene TGFB1 and neoplasm.