Immunosuppressive monocytes are gained by the fusion of tumor-derived exosomes and monocytes, exhibiting as high CD14 expression without HLA-DA expression [90], and CD14+HLA-DRlo/neg monocytes, as tumor-induced immunosuppressive mediator, have been proved to increase in serum of many cancers, such as pancreatic cancer [91]. This evidence concerns the gene CD14 and familial pancreatic carcinoma.