Based on the obtained data, the expression of Sox9, collagen type II, and aggrecan genes in the groups treated with AD-Exo and BM-Exo showed a significant increase in comparison to the OA group (p ≤ 0.05), while there was no significant difference between exosome-treated groups and normal mice (p > 0.05). The gene discussed is ACAN; the disease is Alzheimer disease.