We found that the expression level of GRWD1 was positively correlated with the expression levels of immune checkpoint-related genes (CD274, CTLA4, HAVCR2, LAG3, PDCD1, PDCD1LG2, SIGLEC15, and TIGIT) in most types of cancer, especially in STAD. The gene discussed is CD274; the disease is gastric adenocarcinoma.