ACE and hydrops fetalis: On the other hand, the Prospective Randomized Study of Ventricular Failure and the Efficacy of Digoxin (PROVED) (10) and Randomized Assessment of Digoxin on Inhibitors of Angiotensin-Converting Enzyme (RADIANCE) (11) studies were designed to assess the effect of DGX withdrawal on patients with stable systolic HF [New York Heart Association (NYHA) II–III and LVEF ≤ 35%]; they found that DGX withdrawal did not improve the life quality of patients with HF.