IL6 and ischemia: However, the concentration of three cytokines, KC/GRO (CXCL1), IL-6, and TNFα, were showed to be significantly increased in the coronary effluents of the hearts after IR injury (after ischemia and 60 min of reperfusion) compared with the basal conditions (collected at 10 min stabilization, basal) (Figure 1C).