Fu et al. (2016) found that HOTAIR promotes tumor cell growth and angiogenesis by directly activating VEGFA and Ang2 expression in nasopharyngeal carcinoma cells. Li et al. (2014) found that in metastatic breast cancer, HOTAIR promotes the angiogenesis of breast epithelial cells through transcriptional activation of VEGF-C, thereby promoting tumor metastasis. The gene discussed is VEGFA; the disease is neoplasm.