Circ-ATXN1 (Liu X. et al., 2020), circ-SHKBP1 (Xie et al., 2020), and circ-001971 (Chen et al., 2020) mainly regulate VEGF through sponging miRNAs and activate PI3K/AKT signaling pathway to promote tumor cell proliferation, migration and angiogenesis. Here, VEGFA is linked to neoplasm.