HOTAIR and neoplasm: LncRNAs such as HOTAIR (Li et al., 2014; Yu and Li, 2015; Fu et al., 2016; Zhou et al., 2020), MALAT1, ANRIL and SRA are up-regulated in tumors and play the role of oncogenes, while MEG3, GASS and LncRNA-p21 are down-regulated in tumors and play a role of tumor suppressors.