Tumor-associated neovasculature is a complex physiological incident, which is governed by a variety of pro- or anti-angiogenic cytokines and multiple signaling pathways, such as vascular endothelial growth factor (VEGF; Apte et al., 2019), angiopoietin (Carbone et al., 2018), etc. The gene discussed is VEGFA; the disease is neoplasm.