In a cerebral ischemia/reperfusion model, ONOO– induced the tyrosine nitration of dynamin-related protein 1 (Drp1) peptide and recruitment of Drp1 to damage mitochondria and subsequently induce PINK1/Parkin-mediated autophagy activation, thereby promoting brain ischemia/reperfusion injury (Feng et al., 2018a,b). This evidence concerns the gene PRKN and brain ischemia.