Moreover, reduced PABPN1 levels in mouse adult skeletal muscle affect polyadenylation site utilization within the 3′-UTR of several mRNAs associated with OPMD, resulting in the usage of more proximal alternative polyadenylation sites (de Klerk et al., 2012; Abbassi-Daloii et al., 2017; Raz et al., 2017). Here, PABPN1 is linked to oculopharyngeal muscular dystrophy.