YTHDF2 and liver cancer: Furthermore, Niu et al. (2021) recently showed that the posttranscriptional regulation of the abnormal expression of aldolase A (ALDOA) under hypoxia was positively modulated by FTO-mediated m6A RNA modification in a YTHDF2-dependent manner in liver cancer cells, and hypoxia-mediated high level of ALDOA contributed to liver cancer development by promoting glycolysis metabolism and its terminal product lactate expression.