In addition, upregulation of METTL3 in gastric cancer promotes tumor angiogenesis and glycolysis by promoting IGF2BP3-dependent hepatoma-derived growth factor (HDGF) mRNA stability, which is essential for increasing in glycolysis by activating GLUT4 and ENO2 in gastric cancer cells (Wang et al., 2020c). Here, ENO2 is linked to gastric cancer.