METTL3 and neoplasm: In addition, upregulation of METTL3 in gastric cancer promotes tumor angiogenesis and glycolysis by promoting IGF2BP3-dependent hepatoma-derived growth factor (HDGF) mRNA stability, which is essential for increasing in glycolysis by activating GLUT4 and ENO2 in gastric cancer cells (Wang et al., 2020c).