In addition, upregulation of METTL3 in gastric cancer promotes tumor angiogenesis and glycolysis by promoting IGF2BP3-dependent hepatoma-derived growth factor (HDGF) mRNA stability, which is essential for increasing in glycolysis by activating GLUT4 and ENO2 in gastric cancer cells (Wang et al., 2020c). This evidence concerns the gene METTL3 and gastric cancer.