Through a similar mechanism, EVs expressing GAGs released by glioblastoma bind to, and are decorated with, chemokine ligand CCL18, facilitating their interaction with cognate receptor CCR8 on recipient glioblastoma cells (Berenguer et al., 2018) to increase uptake and induce a proliferative phenotype (Berenguer et al., 2018). The gene discussed is CCL18; the disease is glioblastoma.