Some studies have shown that E3330 decreases the expression of inflammatory modulators, such as tumor necrosis factor-α (TNF-α) and interleukin IL-8, and inhibits the growth and migration of cancer cells (Fishel et al., 2011; Kelley et al., 2011; Su et al., 2011; Li and Wilson, 2014; Ding et al., 2017). The gene discussed is TNF; the disease is cancer.