It has been reported that natural killer (NK) cells and cytotoxic T lymphocytes could kill cancer cells by releasing granzyme A (GZMA) to cleave GSDMB (Zhou et al., 2020) and granzyme B (GZMB) to directly cleave GSDME to activate pyroptosis in cancer cells (Zhang et al., 2020). The gene discussed is GSDME; the disease is cancer.