EGFR and non-small cell lung carcinoma: For example, PAQR3 enhances autophagy induced by the EGFR inhibitor erlotinib to inhibit the growth of NSCLC cells, and a combination therapy, including lipophilic bisphosphonates, facilitates autophagy, and prevents KRAS-driven LUAD cell proliferation (Xia et al., 2014).