While SRSF10 has been reported in different model systems including colon cancer (Zhou et al., 2014b), cervical cancer (Liu et al., 2018) for its role in the regulation of AS, its deregulation in HNC has remained to be elucidated, which is the sixth most common cancer worldwide (Parkin et al., 2005). The gene discussed is SRSF10; the disease is malignant colon neoplasm.