Interestingly, EGR1 is shown to function as an oncogene in prostate cancer (Virolle et al., 2003), and EGR1 mediated expression of its target genes involves EGR1mediated recruitment of TET1 at the EGR1 binding site which further promote the demethylation (hydroxymethylation), elevating the expression of the EGR1 target gene in neuronal cells (Sun et al., 2019). This evidence concerns the gene TET1 and Familial prostate cancer.