Next, we validated the expression of BCLx isoforms (Supplementary Figure 3B) and PKM isoforms (Supplementary Figure 3C) in the HNC tissue samples obtained from patients under treatment at the Bansal Hospital, Bhopal, and we observed the higher PKM2 and low PKM1 expression in HNC tumor tissue samples in comparison to paired normal tissue samples at the RNA level (Figure 5A). The gene discussed is PKM; the disease is neoplasm.