During the current study, we examined the expression of LCN2 was significantly upregulated and that they could play a significant role in liver pathological changes caused by S. japonicum, such as acute liver granuloma and liver fibrosis, and we validated the difference between normal groups and schistosomiasis groups, then we investigated three pairs of infected subject liver tissues and the respective non-infected ones. The gene discussed is LCN2; the disease is schistosomiasis.