Kling et al. found that under hypoxic conditions, the Ewing’s sarcoma cells A673 and SK-ES-1 upregulate and load miR-210 in their EVs, which suppresses Caspase 8 Associated Protein 2 (CASP8AP2) expression in parental cells, eventually inhibiting OS cells apoptosis and inducing a stem-like phenotype (60). This evidence concerns the gene CASP8AP2 and Ewing sarcoma.