Alpha-fetoprotein (AFP), Neutrophil-to-Lymphocyte Ratio (NLR), Glypican-3 (GPC3) and other indicators were considered to indicate the prognosis of patients with hepatocellular carcinoma, but because of the complex molecular mechanism and strong heterogeneity of hepatocellular carcinoma, these indicators still have some limitations (4). Here, GPC3 is linked to hepatocellular carcinoma.