GEPIA2021 analysis resulted that among the five kinds of immune cells including B cells, CD4+ T cells, CD8+ T cells, macrophages, and NK cells, KPNA2 expression was lower in CD4+T cells (p = 0.02) and macrophages (p < 0.01) in HCC tumors in comparison with that in normal liver tissues, as shown in Fig. 7. This evidence concerns the gene CD8A and hepatocellular carcinoma.