KPNA2 and hepatocellular carcinoma: For KPNA2 gene mutation inquiry in the GDC portal (https://portal.gdc.cancer.gov/), only four patients in TCGA-HCC dataset were found to have KPNA2 mutations and no significant KPNA2 expression difference was revealed between the HCC samples with and without KPNA2 mutation (p = 0.69, Fig. S1).