Four CpG sites locating in KPNA2 promoter including cg23206777, cg22429852, cg21018429, and cg21820889 presented negative correlations (p < 0.05, Figs. 1B–1E) with KPNA2 expression respectively in HCC, indicating their potential roles in regulating KPNA2 expression. Here, KPNA2 is linked to hepatocellular carcinoma.