KPNA2 and hepatocellular carcinoma: When adjusted with age, gender, and tumor stage, the methylation status of two CpG sites of cg23206777 (p = 0.026) and cg17985418 (p = 0.00258) was shown to have a favorable or an unfavorable prognostic effect on HCC OS respectively, while KPNA2 CNV and other KPNA2 CpG sites presented no significant correlation with HCC OS (Table S3).