When adjusted with age, gender, and tumor stage, the methylation status of two CpG sites of cg23206777 (p = 0.026) and cg17985418 (p = 0.00258) was shown to have a favorable or an unfavorable prognostic effect on HCC OS respectively, while KPNA2 CNV and other KPNA2 CpG sites presented no significant correlation with HCC OS (Table S3). This evidence concerns the gene KPNA2 and neoplasm.