Levi et al. (2020) have noted that low-grade DIC often seen in COVID-19 is associated with a sudden decrease in plasma fibrinogen before death. This makes the connection with the various fibrinogen subcomponents even more striking. Our network data suggest that ACE2’s connection to fibrinogen is mediated through Clusterin and GPR141 (Fig. 3). The chaperone protein Clusterin’s role in removing misfolded proteins in the blood and its common association with fibrinogen in blood plasma (Wyatt & Wilson, 2010) lend credence to these ERC findings. The gene discussed is GPR141; the disease is COVID-19.